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Biofreeze products contain Ilex, an herbal extract from a South American holly shrub. Ilex is used around the world in various health & wellness formulations. Biofreeze topical analgesic does not use waxes, oils, aloe or petroleum. The result is a fast-acting, penetrating, long lasting pain reliever. Biofreeze pain reliever's unique, cooling formulation is also comforting to sore muscles and muscle sprains; easing back, shoulder and neck pain; reducing painful ankle, knee, hip and elbow joints and helping to lessen effects of muscular strains.